Welcome to Matrix Dynamics

The group was established in 1973 with funding from the Medical Research Council of Canada, now known as the Canadian Institute of Health Research. Originally the group focused on the regulation of cells from the periodontium and was known as the MRC Group in Periodontal Physiology. The group currently is headed by the program director, Dr. Christopher McCulloch and focuses on the regulation of connective tissue matrix proteins in health and disease. The Groups major strength is in bringing a full specturm of scientific and technical experience to the issues of matrix remodelling and the signalling networks that control remodelling. VIDEO INTRO FROM THE DIRECTORLEARN MORE ABOUT OUR RESEARCH CORES

Matrix Dynamics Research Cores

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Cell Culture Core

Dedicated technologist and hands-on teaching for primary cultures and lines of fibroblasts, osteoblasts, chondrocytes, myocytes for:

  • Mineralized tissue
  • Cardiac ligament
  • Periodontal ligament
  • Myeloid differentiation
  • Knock-out primary cells and lines for matrix, cytoskeletal, singling proteins

Imaging Core

Dedicated technologist and hands-on teaching for:

  • Leica confocal
  • PTI Ratio fluorimetry
  • Nikon TIRF
  • Nikon Wide Field
  • Beckman-Coulter Altra flow cytometer

Animal Core

Dedicated technologist and hands-on teaching for:

  • Knockout mouse models for fibroblast, osteoblast and neutrophil physiology
  • Animal models for arthritis, periodontal, cardiac, inflammatory bowel diseases
  • Coe-Lox technology for conditional knockouts

Proteomics Core

Dedicated technologist and hands-on teaching for:

  • Protein-Protein interactions
  • ICAT and ITRAQ for expression and interaction studies
  • Tandem mass spectrometry
  • Organelles protein identification
  • Matrix protein post -translational modifications